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(Ebook PDF) Deoxynucleoside Analogs In Cancer Therapy 1st Edition by Godefridus Peters 1588293275 9781588293275 Full chapter

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Deoxynucleoside Analogs In Cancer Therapy 1st Edition Marçal Pastor-Anglada Msc Digital Instant Download

Author(s): Marçal Pastor-Anglada MSc, PhD (auth.), Godefridus J. Peters PhD (eds.)
ISBN(s): 9781597451482, 1597451487
Edition: 1
File Details: PDF, 3.77 MB
Year: 2007
Language: english
SKU: EB-4395866 Category: Tags: , ,

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ISBN 10:         1588293275
ISBN 13: 978-1588293275
Author:          Godefridus J Peters

Successful cancer chemotherapy relies heavily on the application of various deoxynucleoside analogs. Since the very beginning of modern cancer chemotherapy, a number of antimetabolites have been introduced into the clinic and subsequently applied widely for the treatment of many malignancies, both solid tumors and hematological disorders. In the latter diseases, cytarabine has been the mainstay of treatment of acute myeloid leukemia. Although many novel compounds were synthesized in the 1980s and 1990s, no real improvement was made. However, novel technology is now capable of elucidating the molecular basis of several inborn errors as well as some specific malignancies. This has enabled the synthesis of several deoxynucleoside analogs that could be applied for specific malignancies, such as pentostatin and subsequently chlorodeoxyadenosine (cladribine) for the treatment of hairy cell leukemia. Already in the early stage of deoxynucleoside analog development, it was recognized that several of these compounds were very effective in the treatment of various viral infections, such as for the treatment of herpes infections. This formed the basis initially for the design of azidothymidine and subsequently many other analogs, which are currently successfully used for the treatment of HIV infections. As a spin-off of these research lines, some compounds not eligible for development as antiviral agents appeared to be very potent anticancer agents. The classical example is gemcitabine, now one of the most widely applied deoxynucleoside analogs, used for the (combination) treatment of non-small cell lung cancer, pancreatic cancer, bladder cancer, and ovarian cancer.
 

Deoxynucleoside Analogs In Cancer Therapy 1st  Table of contents:

 

1. Introduction to Deoxynucleoside Analogs in Cancer Therapy

  • Overview of Cancer Treatment
  • The Role of Deoxynucleoside Analogs in Cancer Therapy
  • Mechanisms of Action of Deoxynucleoside Analogs
  • Clinical Relevance of Deoxynucleoside Analogs

2. Chemistry and Structure of Deoxynucleoside Analogs

  • Basic Chemical Structures of Deoxynucleosides
  • Modifications in Deoxynucleoside Analog Design
  • Structure-Activity Relationship of Deoxynucleoside Analogs
  • Chemical Synthesis and Development

3. Mechanisms of Action of Deoxynucleoside Analogs

  • Inhibition of DNA Synthesis
  • Interaction with DNA Polymerases
  • Induction of DNA Damage and Apoptosis
  • Impact on Nucleotide Metabolism
  • Resistance Mechanisms

4. Key Deoxynucleoside Analogs in Cancer Therapy

  • Cytarabine (Ara-C)
  • Gemcitabine
  • Fludarabine
  • Cladribine
  • 5-Fluorodeoxyuridine and Other Analogues
  • Novel Deoxynucleoside Analogs in Development

5. Clinical Applications of Deoxynucleoside Analogs in Cancer Therapy

  • Acute Leukemias and Lymphomas
  • Solid Tumors: Breast, Lung, and Pancreatic Cancer
  • Combination Therapy with Chemotherapy and Targeted Drugs
  • Personalized Medicine Approaches

6. Pharmacokinetics and Drug Delivery of Deoxynucleoside Analogs

  • Absorption, Distribution, Metabolism, and Excretion (ADME)
  • Bioavailability and Half-Life of Deoxynucleoside Analogs
  • Drug Delivery Systems: Liposomes, Nanoparticles, and Others
  • Modulating Pharmacokinetics for Efficacy

7. Toxicity and Side Effects of Deoxynucleoside Analogs

  • Common Toxicities and Side Effects
  • Dose-Limiting Toxicities (DLTs)
  • Long-Term Toxicity and Organ-Specific Effects
  • Managing Adverse Effects in Patients

8. Resistance to Deoxynucleoside Analogs

  • Mechanisms of Drug Resistance
  • Genetic Mutations in Enzymes and Transporters
  • Overcoming Resistance: Strategies and Approaches
  • Clinical Implications and Solutions

9. Future Directions and Advances in Deoxynucleoside Analogs

  • Development of New and More Potent Analogs
  • The Role of Epigenetics in Drug Sensitivity and Resistance
  • Combining Deoxynucleoside Analogs with Immunotherapies
  • Clinical Trials and Emerging Data

 

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