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Exploring the Human Plasma Proteome 1st Edition by Gilbert Omenn ISBN 978-3527317578 3527317570

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Exploring the Human Plasma Proteome 1st Edition Gilbert S. Omenn (Editor) Digital Instant Download

Author(s): Gilbert S. Omenn (Editor)
ISBN(s): 9783527317578, 3527317570
Edition: 1
File Details: PDF, 18.71 MB
Year: 2006
Language: english
SKU: EB-2163824 Category: Tag:

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Product details: 

ISBN 10: 3527317570

ISBN 13:  978-3527317578

Author:  Gilbert S. Omenn

On the cutting edge of medical diagnostics, plasma proteomics promises to generate a new wave of technologies to help identify many different diseases and disease risks.
Plasma and serum are the preferred non-invasive specimens to test normal individuals, at-risk groups, and patients for protein biomarkers discovered and validated to reflect physiological, pathological, and pharmacological phenotypes. These specimens present enormous challenges due to extreme complexity, huge dynamic range in protein concentrations, non-standardized methods of sample processing, and intra- and inter-individual variation from genetics, diet, smoking, hormones, and other sources. This book presents the major findings from the collaborative Plasma Proteome Project organized by the international Human Proteome Organization (HUPO). The chapters are drawn from a larger set of publications in the journal PROTEOMICS. This book provides a valuable foundation for development and applications of proteomics.

Table of contents: 

  1. Exploring the Human Plasma Proteome

  2. Overview of the HUPO Plasma Proteome Project

  3. Data management and preliminary data analysis in the pilot phase of the HUPO Plasma Proteome Project

  4. HUPO Plasma Proteome Project specimen collection and handling: Towards the standardization of parameters for plasma proteome samples

  5. Immunoassay and antibody microarray analysis of the HUPO Plasma Proteome Project reference specimens: Systematic variation between sample types and calibration of mass spectrometry data

  6. Depletion of multiple high-abundance proteins improves protein profiling capacities of human serum and plasma

  7. Differences among techniques for high-abundant protein depletion

  8. Immunoaffinity separation of plasma proteins by IgY microbeads: Meeting the needs of proteomic sample preparation and analysis

  9. A novel four-dimensional strategy combining protein and peptide separation methods enables detection of low-abundance proteins in human plasma and serum proteomes

  10. A wide range of protein isoforms in serum and plasma uncovered by a quantitative intact protein analysis system

  11. A study of glycoproteins in human serum and plasma reference standards (HUPO) using multilectin affinity chromatography coupled with RPLC-MS/MS

  12. Evaluation of prefractionation methods as a preparatory step for multidimensional based chromatography of serum proteins

  13. Utility of electrophoretically derived protein mass estimates as additional constraints in proteome analysis of human serum based on MS/MS analysis

  14. Efficient prefractionation of low-abundance proteins in human plasma and construction of a two-dimensional map

  15. Two-dimensional liquid chromatography/tandem mass spectrometry analysis of GradiflowTM fractionated native human plasma

  16. Application of 2-D free-flow electrophoresis/RP-HPLC for proteomic analysis of human plasma depleted of multi high-abundance proteins

  17. Peptidomic analysis of human blood specimens: Comparison between plasma specimens and serum by differential peptide display

  18. Comparison of alternative analytical techniques for the characterisation of the human serum proteome in HUPO Plasma Proteome Project

  19. The human plasma proteome: Analysis of Chinese serum using shotgun strategy

  20. A proteomic study of the HUPO Plasma Proteome Project’s pilot samples using an accurate mass and time tag strategy

  21. Analysis of Human Proteome Organization Plasma Proteome Project (HUPO PPP) reference specimens using surface enhanced laser desorption/ionization-time of flight (SELDI-TOF) mass spectrometry: Multi-institution correlation of spectra and identification of biomarkers

  22. An evaluation, comparison, and accurate benchmarking of several publicly available MS/MS search algorithms: Sensitivity and specificity analysis

  23. Centralized data analysis of a large interlaboratory proteomics project: A feasibility study

  1. Human Plasma PeptideAtlas

  2. Do we want our data raw? Including binary mass spectrometry data in public proteomics data repositories

  3. A functional annotation of subproteomes in human plasma

  4. Cardiovascular-related proteins identified in human plasma by the HUPO Plasma Proteome Project Pilot Phase

  5. Plasma Proteome Database as a resource for proteomics research

  6. PRIDE: The proteomics identifications database

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Tags: Gilbert Omenn, Exploring the Human, Plasma Proteome