Update on Polymer Based Nanomedicine 1st Edition by Andreas M Nystrom ISBN 978-1847357472 1847357474

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Product details: 

ISBN 10: 1847357474

ISBN 13: 978-1847357472

Author: Andreas M Nystrom

Polymers are one of the most applicable and clinically relevant materials for constructing nanomedical systems. These systems are expected to have a future in the clinic; nanomedical constructs will have wide implications for how we treat and diagnose society’s most complex diseases, such as cancer, inflammation and genetic disorders.

This book focuses on describing the fundamentals of controlled polymerisation techniques and methods for constructing advanced polymer architectures to be used in polymer based nanomedicine. We review this growing field, which uses recent advances in polymer chemistry and conjugation techniques to construct advanced nanoparticles. One focus of this book is to give examples of recent developments in drug delivery, ligand targeted therapy and diagnostic imaging techniques. One section is devoted to the latest developments in nanomedicine – theranostic systems – which combine therapeutic delivery with diagnostic imaging capabilities in the same device. Such systems will play a crucial role in developing personalised medicine.

Table of contents: 

1 Introduction to Nanomedicine

1.1 Benefits of Nanomedicine

2 Polymer Materials used in Nanomedicine Applications.

2.1 Types of Polymer

2.1.1 Linear Polymers.

2.1.2 Block Copolymers.

2.1.3 Graft Copolymers.

2.1.4 Dendritic Polymers

2.1.4.1 Common Dendrimer Types

2.1.4.2 Nanomedical Uses of Dendrimers..

2.2 Controlled Synthesis

2.2.1 Atom Transfer Radical Polymerisation..

Reversible Addition-fragmentation Chain Transfer

2.2.3 Nitroxide-mediated Polymerisation

2.3 Polymer-based Structures for Nanomedicine.

2.3.1 Micelles and Nanoparticles.

2.3.2 Hydrogel Nanoparticles (Nanogels).

3.Medical Applications of Polymer-based Nanosystems

3.1 Applications

3.1.1 Physical Encapsulation Systems

3.1.2 Covalent Encapsulation Systems

3.1.3 Targeted Nanomedicine Systems

3.1.4 Polymer Modification of Biological Drugs

3.1.4.1 Grafting of Polymers from Biomacromolecules-

3.1.4.2 Grafting of Polymers to Biomacromolecules

3.2. Diagnostic Imaging Applications

3.2.1 Magnetic Resonance Imaging

3.2.2 Positron Emission Tomography.

3.2.3 Computerised Tomography.

3.2.4 Optical Imaging.

3.2.5 Ultrasound

3.3 Polymerbased Theranostic Devices.

3.3.1 Combined Agents

4. Challenges for Polymer-based Nanomedicine

4.1 Toxicity.

4.2 Degradability

4.3 Reproducibility.

5 Outlook

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Tags: Andreas M Nystrom, Update on Polymer, Based Nanomedicine