Epigenetic Cancer Therapy 1st Edition by Steven Gray ISBN 0128002069 978-0128002063

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Product details: 

ISBN 10: 0128002069 

ISBN 13: 978-0128002063

Author:  Steven Gray

Epigenetic Cancer Therapy unites issues central to a translational audience actively seeking to understand the topic. It is ideal for cancer specialists, including oncologists and clinicians, but also provides valuable information for researchers, academics, students, governments, and decision-makers in the healthcare sector.

The text covers the basic background of the epigenome, aberrant epigenetics, and its potential as a target for cancer therapy, and includes individual chapters on the state of epigenome knowledge in specific cancers (including lung, breast, prostate, liver).

The book encompasses both large-scale intergovernmental initiatives as well as recent findings across cancer stem cells, rational drug design, clinical trials, and chemopreventative strategies. As a whole, the work articulates and raises the profile of epigenetics as a therapeutic option in the future management of cancer.

Concisely summarizes the therapeutic implications of recent, large-scale epigenome studies, including the cancer epigenome atlas
Discusses targeted isoform specific versus pan-specific inhibitors, a rational drug design approach to epigenetics relevant to pharmacoepigenetic clinical applications
Covers new findings in the interplay between cancer stem cells (CSCs) and drug resistance, demonstrating that epigenetic machinery is a candidate target for the eradication of these CSCs

Table of contents: 

1 Introduction to the Area (Key Concepts)
2 Epigenetics and Cancer
3 Targeting Aberrant Epigenetics
4 Issues to Overcome/Areas of Concern
5 Future Directions. Translation to the Clinic

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