Principles of Nucleic Acid Structure 1st Edition by Stephen Neidle ISBN 9780080553528 0080553528
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Product details:
ISBN 10: 0080553528
ISBN 13: 9780080553528
Author: Stephen Neidle
This unique and practical resource provides the most complete and concise summary of underlying principles and approaches to studying nucleic acid structure, including discussion of x-ray crystallography, NMR, molecular modelling, and databases. Its focus is on a survey of structures especially important for biomedical research and pharmacological applications. To aid novices, Principles of Nucleic Acid Structure includes an introduction to technical lingo used to describe nucleic acid structure and conformations (roll, slide, twist, buckle, etc.). This completely updated edition features expanded coverage of the latest advances relevant to recognition of DNA and RNA by small molecules and proteins. In particular, the reader will find extensive new discussions RNA folding, ribosome structure and antibiotic interactions, DNA quadruplexes, DNA and RNA protein complexes, and short interfering RNA (siRNA). This handy guide ends with a complete list of resources, including relevant online databases and software.
Table of contents:
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Methods for Studying Nucleic Acid Structure
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The Building-Blocks of DNA and RNA
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DNA Structure as Observed in Fibers and Crystals
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Nonstandard and Higher-Order DNA Structures: DNA–DNA Recognition
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Principles of Small Molecule-DNA Recognition
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RNA Structures and Their Diversity
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Principles of Protein-DNA Recognition
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Index
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