(Ebook PDF) Biofilms, Infection, and Antimicrobial Therapy 1st edition by John Pace, Mark Rupp, Roge Finch 082472643X 9780824726430 Full chapter
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ISBN 10: 082472643X
ISBN 13: 978-0824726430
Author: John L. Pace, Mark E. Rupp, Roger G. Finch
Rather than existing in a planktonic or free-living form, evidence indicates that microbes show a preference for living in a sessile form within complex communities called biofilms. Biofilms appear to afford microbes a survival advantage by optimizing nutrition, offering protection against hostile elements, and providing a network for cell-to-cell signaling and genetic exchange.
Biofilms, Infection, and Antimicrobial Therapy provides an in-depth exploration of biofilms, offering broad background information, as well a detailed look at the serious concerns to which biofilm-associated infections give rise.
Prosthetic device infections, such as those involving artificial heart valves, intravascular catheters, or prosthetic joints, are prime examples of biofilm-associated infections. With the increasing use of such devices in the modern practice of medicine, the prevalence of these infections is expected to increase. Unfortunately, one of the most troubling characteristics of microbes found in biofilms is a profound resistance to antimicrobial agents.
As biofilm-associated infections are particularly difficult to treat, they result in significant mortality, morbidity, and increased economic burden. Clearly, a better understanding of the pathogenesis of these infections and improved means for prevention and treatment are urgently needed!
InBiofilms, Infection, and Antimicrobial Therapy, Drs Pace, Rupp, and Finch assemble the contributions of more than 50 of the world’s leading authorities on microbial biofilms who present recent findings on antibacterial tolerance and bacterial persistence associated with biofilms and discuses the implications of those findings with regard to human health. They explore the molecular mechanisms of bacterial adherence, biofilm formation, regulation of biofilm maintenance, and cell-to-cell communication and present the latest information on various treatment protocols that should aid physicians in the treatment o
Biofilms, Infection, and Antimicrobial Therapy 1st Table of contents:
Section I Biofilms: Background, Significance, and Roles of Catheters and Indwelling Devices
1 Microbial Biofilms
2 Economic Impact of Biofilms on Treatment Costs
3 Biofilm-Related Indwelling Medical Device Infections
4 Medical Device Composition and Biological Secretion Influences on Biofilm Formation
Section II Biofilm-Forming Pathogens
5 Role of Biofilms in Infections Caused by
6 Staphylococcus aureus Biofilms
7 Coagulase-Negative Staphylococci
8 Pseudomonas aeruginosa Biofilm Infections in Cystic Fibrosis
9 Candida
Section III Emerging Issues, Assays, and Models
10 n Current Perspectives on the Regulation of the ica Operon and Biofilm Formation in Staphylococcus epidermidis
11 Cell-to-Cell Communication in Bacteria
12 Persisters: Specialized Cells Responsible for Biofilm Tolerance to Antimicrobial Agents
13 Minimal Biofilm Eradication Concentration (MBEC) Assay: Susceptibility Testing for Biofilms
14 Environmental Cues Regulate Virulence and Biofilm Formation
15 In Vivo Models 15 for the Study of Biomaterial-Associated Infection by Biofilm-Forming Staphylococci
16 Host Response to Biofilms
Section IV: Overview of Antiinfective Agents and Clinical Therapy
17 Pharmacodynamics and the Treatment of IMD-Related Infections
18 Protein Synthesis Inhibitors, Fluoroquinolones, and Rifampin for Biofilm Infections
‘t Q ß-Lactams for the Treatment of Biofilm-Associated Infections
20 Glycopeptide Antibacterials and the Treatment of Biofilm-Related Infections
21 Antibiotic Resistance in Biofilms
22 Treatment Protocols for Infections of Vascular Catheters
QO Treatment Protocols for Bacterial Endocarditis and Infection of Electrophysiologic Cardiac Devices
24 Treatment Protocol of Infections of Orthopedic Devices
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