Basement membranes First Edition by Jeffrey Miner ISBN 978-0128040157 0128040157
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Product details:
ISBN 10: 0128040157
ISBN 13: 978-0128040157
Author: Jeffrey H. Miner
Basement Membranes focuses on specialized extracellular matrices that provide the scaffolds used and required by cells to organize themselves into tissues and organs. As basement membranes have been shown to be defective in numerous genetic and acquired diseases and to contribute to the microenvironment of both tumor cells and stem cells, this book presents a view of specific basement membrane components and their roles in development and disease, all written and commented on in chapters written by leaders in the basement membrane field.
- Written by leading experts in the basement membrane field
- Contains original material, both textual and illustrative, that should become a very relevant reference material
- Presents material in a very comprehensive manner
- Ideal for both researchers in the field and general readers who will find relevant and up-to-date information
Table of contents:
Chapter One. Integrating Activities of Laminins that Drive Basement Membrane Assembly and Function
1. Introduction
2. The Laminin Family
3. Laminin Polymerization
4. Laminin Adhesion to Cell Surfaces and Anchorage to Cytoskeleton
5. Laminin Polymerization on Cell Surfaces
6. Adaptor Proteins that Bind to Laminins: Nidogen, Perlecan, and Agrin
7. Type IV Collagen Network
8. Laminin-Deficient Muscular Dystrophy and Neuropathy
9. Pierson Syndrome
10. Conclusions
Chapter Two. Laminin-α2 Chain-Deficient Congenital Muscular Dystrophy: Pathophysiology and Development of Treatment
1. Introduction
2. Laminin-211 and Cell Surface Receptors
3. Clinical Phenotype of MDC1A
4. Animal Models of MDC1A
5. Pathogenesis of MDC1A
6. Amelioration of Disease in Mice
7. Conclusion
Chapter Three. Type IV Collagens and Basement Membrane Diseases: Cell Biology and Pathogenic Mechanisms
1. Genomic Organization and Protein Structure of Type IV Collagens
2. Type IV Collagen Biosynthesis
3. Type IV Collagen-Related Pathology
4. Mechanisms for Type IV Collagen-Related Pathology
Chapter Four. Epidermal Basement Membrane in Health and Disease
1. Introduction
2. Composition and Architecture of the Epidermal BM and Associated Adhesion Structures
3. The Role of Components of the Epidermal BM in Cutaneous Regeneration
4. Disorders of the Epidermal BM
5. Conclusions and Future Prospects
Chapter Five. Applying Proteomics to Investigate Extracellular Matrix in Health and Disease
1. Introduction
2. Mass Spectrometry-Based Proteomics
3. Enrichment of ECM for Proteomic Analysis
4. Defining the Matrisome
5. Proteomics of ECM in Health and Disease
6. Emerging Techniques
7. Summary
Chapter Six. Molecular Basis of Laminin–Integrin Interactions
1. Introduction
2. Laminin Receptors
3. Ligand Specificities of Laminin-Binding Integrins
4. Mechanisms Underlying the Recognition of Laminins by Integrins
5. Molecular Mechanisms of Laminin Action through Integrins
6. The Roles of Tetraspanins in the Regulation of Laminin-Binding Integrins
7. Conclusions
Chapter Seven. Cell Receptor–Basement Membrane Interactions in Health and Disease: A Kidney-Centric View
1. Basement Membrane Components in Healthy and Diseased Kidney
2. The Alport Mouse Models of Kidney Disease
3. Laminins and Mouse Models of Glomerular Kidney Disease
4. Laminins and Renal Epithelial Cell Homeostasis
5. Nidogens and Heparan Sulfate Proteoglycans in Kidney Homeostasis
6. Basement Membrane Modifying Enzymes in Health and Disease
7. Integrins in Healthy and Diseased Kidney
8. Conclusions
Chapter Eight. The Basement Membrane Proteoglycans Perlecan and Agrin: Something Old, Something New
1. Introduction
2. A Succinct Historical Perspective
3. Basement Membrane Proteoglycan Core Proteins
Chapter Nine. Building from the Ground up: Basement Membranes in Drosophila Development
1. Introduction
2. Synthesis, Secretion, and Assembly of BMs on Basal Cell Surfaces
3. Mechanical Contributions of the BM to Morphogenesis
4. Contributions of the BM to Cell–Cell Signaling during Development
5. Conclusion
Chapter Ten. Basement Membranes in the Worm: A Dynamic Scaffolding that Instructs Cellular Behaviors and Shapes Tissues
1. Introduction
2. Basement Membrane Assembly in the Worm: Diverse Compositions Determined by Local Interactions and Recruitment of Matrix Components
3. Basement Membranes Instruct Diverse Cellular Behaviors and Shape Tissues
4. Creating Gaps in—or Links between—Basement Membranes Helps Shape Tissues
5. Future Directions and Perspectives
6. Conclusion
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