Pathogenesis of Neurodegenerative Disorders 1st Edition by Mark Mattson ISBN ‎ 978-1617372155 ‎ 1617372153

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Product details: 

ISBN 10:  ‎ 1617372153

ISBN 13: ‎ 978-1617372155

Author: Mark P. Mattson

As the average life expectancy of many populations throughout the world increases, so to does the incidence of such age-related neurodegenerative disorders as Alzheimer’s, Parkinson’s, and Huntington’s diseases. Rapid advances in our understanding of the molecular genetics and environmental factors that either cause or increase risk for age-related neurodegenerative disor­ ders have been made in the past decade. The ability to evaluate, at the cellular and molecular level, abnormalities in postmortem brain tissue from patients, when taken together with the development of valuable animal and cell-culture models of neurodegenerative disorders has allowed the identification of sequences of events within neurons that result in their demise in specific neurodegenerative disorders. Though the genetic and environmental factors that pro­ mote neurodegeneration may differ among disorders, shared biochemical cascades that will ultimately lead to the death of neurons have been identified. These cascades involve oxyradical production, aberrant regulation of cellular ion homeostasis and activation of a stereotyped sequence of events involving mitochondrial dysfunction and activa­ tion of specific proteases. Pathogenesis of Neurodegenerative Disorders provides a timely compilation of articles that encompasses fundamental mechanisms involved in neurodegenerative disorders. In addition, mechanisms that may prevent age-related neurodegenerative disorders are presented. Each chapter is written by an expert in the particular neurodegenerative disorder or mechanism or neuronal death discussed.

Table of contents: 

1. Mechanisms of Neuronal Apoptosis and Excitotoxicity
   Mark P. Mattson

2. Oxidative Alterations in Neurodegenerative Diseases
   William R. Markesbery, Thomas J. Montine, and Mark A. Lovell

3. Parkinson’s Disease
   M. T. Silva and A. H. V. Schapira

4. Scope of Trinucleotide Repeat Disorders
   Shoji Tsuji

5. Mechanisms of Neuronal Death in Huntington’s Disease
   Vassilis E. Koliatsos, Carlos Portera-Cailliau, Gabrielle Schilling, David B. Borchelt, Mark W. Becher, and Christopher A. Ross

6. Cellular and Molecular Mechanisms Underlying Synaptic Degeneration and Neuronal Death in Alzheimer’s Disease
   Mark P. Mattson, Ward A. Pedersen, and Carsten Culmsee

7. Oxidative Stress in Down Syndrome: A Paradigm for the Pathogenesis of Neurodegenerative Disorders
   Rocco C. Iannello and Ismail Kola

8. The Pathogenesis of Amyotrophic Lateral Sclerosis (ALS)
   Stanley H. Appel and R. Glenn Smith

9. Experimental Genetics as a Tool for Understanding Pathogenesis of ALS
   Philip C. Wong, Donald L. Price, and Jamuna Subramaniam

10. Pathogenesis of Ischemic Stroke
    Mark P. Mattson and Carsten Culmsee

11. Spinal-Cord Injury
    Isabel Klusman and Martin E. Schwab

12. The Pathogenesis of Duchenne Muscular Dystrophy
    Edward A. Burton and Kay E. Davies

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