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Anticancer Drug Development Guide Cancer Drug Discovery and Development 1st Edition by Beverly Teicher, Paul Andrews ISBN 9781468498417 1468498417

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Anticancer Drug Development Guide Cancer Drug Discovery and Development 1st Edition Beverly Teicher Digital Instant Download

Author(s): Beverly Teicher, Paul Andrews
ISBN(s): 9781592597390, 1592597394
Edition: 1
File Details: PDF, 4.23 MB
Year: 2004
Language: english
SKU: EB-1709624 Category: Tags: ,

Anticancer Drug Development Guide Cancer Drug Discovery and Development 1st Edition by Beverly Teicher, Paul A. Andrews – Ebook PDF Instant Download/Delivery:  978146849841, 1468498417
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Product details: 

ISBN 10: 1468498417

ISBN 13:  9781468498417

Author:  Beverly Teicher, Paul A. Andrews

This unique volume traces the critically important pathway by which a “molecule” becomes an “anticancer agent. ” The recognition following World War I that the administration of toxic chemicals such as nitrogen mustards in a controlled manner could shrink malignant tumor masses for relatively substantial periods of time gave great impetus to the search for molecules that would be lethal to specific cancer cells. Weare still actively engaged in that search today. The question is how to discover these “anticancer” molecules. Anticancer Drug Development Guide: Preclinical Screening, Clinical Trials, and Approval, Second Edition describes the evolution to the present of preclinical screening methods. The National Cancer Institute’s high-throughput, in vitro disease-specific screen with 60 or more human tumor cell lines is used to search for molecules with novel mechanisms of action or activity against specific phenotypes. The Human Tumor Colony-Forming Assay (HTCA) uses fresh tumor biopsies as sources of cells that more nearly resemble the human disease. There is no doubt that the greatest successes of traditional chemotherapy have been in the leukemias and lymphomas. Since the earliest widely used in vivo drug screening models were the murine L 1210 and P388 leukemias, the community came to assume that these murine tumor models were appropriate to the discovery of “antileukemia” agents, but that other tumor models would be needed to discover drugs active against solid tumors.
 

Table of contents: 

  1. Front Matter

  2. In Vitro Methods

  3. High-Volume Screening

  4. The NCI In Vitro Anticancer Drug Discovery Screen

  5. Human Tumor Screening

  6. In Vivo Methods

  7. Murine L1210 and P388 Leukemias

  8. In Vivo Methods for Screening and Preclinical Testing

  9. Human Tumor Xenograft Models in NCI Drug Development

  10. Fertile Seed and Rich Soil

  11. Preclinical Models for High-Dose Therapy

  12. Models for Minimal Residual Tumor

  13. Spontaneously Occurring Tumors in Companion Animals as Models for Drug Development

  14. Clinical Testing

  15. Working with the National Cancer Institute

  16. Phase I Trial Design and Methodology

  17. Phase II Clinical Trials in Oncology

  18. Drug Development in Europe

  19. The Phase III Cancer Clinical Trial

  20. FDA Role in Cancer Drug Development and Requirements for Approval

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Tags: Beverly Teicher, Paul Andrews, Anticancer Drug Development, Drug Discovery