Point mutation 1st Edition by Colin Logie ISBN 9789535103318 9535103318

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Product details: 

ISBN 10:9535103318

ISBN 13: 9789535103318

Author:  Colin Logie 

This book concerns the signatures left behind in chromosomes by the forces that drive DNA code evolution in the form of DNA nucleotide substitutions. Since the genetic code predetermines the molecular basis of life, it could have been about any aspect of biology. As it happens, it is largely about recent adaptation of pathogens and their human host. Nine chapters are medically oriented, two are bioinformatics-oriented and one is technological, describing the state of the art in synthetic point mutagenesis. What stands out in this book is the increasing rate at which DNA data has been amassed in the course of the past decade and how knowledge in this vibrant research field is currently being translated in the medical world.

Table of contents: 

Part 1 — Current Views on Point Mutation Theory
Point Mutations, Their Transition Rates and Involvements in Human and Animal Disorders

Bioinformatical Analysis of Point Mutations in Human Genome

Estimating Human Point Mutation Rates from Codon Substitution Rates

Part 2 — Point Mutation in Viruses: From Drug Resistance to Vaccination
Point Mutations and Antiviral Drug Resistance

Point Mutations Associated with HIV-1 Drug Resistance, Evasion of the Immune Response and AIDS Pathogenesis

Recombination and Point Mutations in Type G Rotavirus Strains: The Challenges of Vaccine Development

Chapter 3
Estimating Human Point Mutation Rates from Codon Substitution Rates

Chapter 4
Point Mutations and Antiviral Drug Resistance

Chapter 5
Point Mutations Associated with HIV-1 Drug Resistance, Evasion of the Immune Response and AIDS Pathogenesis

Chapter 6
Recombination and Point Mutations in Type G Rotavirus Strains: The Challenges of Vaccine Development

Chapter 7
Molecular Attenuation Process in Live Vaccine Generation for Arenaviruses

Part 3 – Point Mutation in Bacteria: Human Activity-Driven Evolution
Chapter 8
Mutational Polymorphism in the Bacterial Topoisomerase Genes Driven by Treatment with Quinolones

Part 4 – Point Mutation in Eukaryote: From Pathogens to Cigarette Smoke
Chapter 9
Point Mutation in Surveillance of Drug-Resistant Malaria

Chapter 10
Correlations with Point Mutations and Severity of Hemolitic Anemias: The Example of Hereditary Persistence of Fetal Hemoglobin with Sickle Cell Anemia and Beta Thalassemia

Chapter 11
Point Mutations That Reduce Erythrocyte Resistance to Oxidative Stress

Chapter 12
Point Mutations in Ferroportin Disease: Genotype/Phenotype Correlation

Chapter 13
p53: Point Mutations, SNPs and Cancer

Chapter 14
Transgenerational Effects of Maternal Nicotine Exposure During Gestation and Lactation on the Respiratory System

Chapter 15
Synthetic Point Mutagenesis

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