Translational Neuroscience Toward New Therapies 1st Edition by Karoly Nikolich, Steven Hyman ISBN 978-0262029865 0262029863
Original price was: $50.00.$35.00Current price is: $35.00.
Translational Neuroscience Toward New Therapies 1st Edition by Karoly Nikolich, Steven E. Hyman – Ebook PDF Instant Download/Delivery: 978-0262029865, 0262029863
Full download Translational Neuroscience Toward New Therapies 1st Edition after payment
Product details:
ISBN 10: 0262029863
ISBN 13: 978-0262029865
Author: Karoly Nikolich, Steven E. Hyman
Experts from academia and industry discuss how to create a new, more effective translational neuroscience drawing on novel technology and recent discoveries.
Today, translational neuroscience faces significant challenges. Available therapies to treat brain and nervous system disorders are extremely limited and dated, and further development has effectively ceased. Disinvestment by the private sector occurred just as promising new technologies in genomics, stem cell biology, and neuroscience emerged to offer new possibilities. In this volume, experts from both academia and industry discuss how novel technologies and reworked translation concepts can create a more effective translational neuroscience.
The contributors consider such topics as using genomics and neuroscience for better diagnostics and biomarker identification; new approaches to disease based on stem cell technology and more careful use of animal models; and greater attention to human biology and what it will take to make new therapies available for clinical use. They conclude with a conceptual roadmap for an effective and credible translational neuroscience—one informed by a disease-focused knowledge base and clinical experience.
Contributors
Tobias M. Böckers, Thomas Bourgeron, Karl Broich, Nils Brose, Bruce N. Cuthbert, Ilka Diester, Gül Dölen, Guoping Feng, Richard Frackowiak, Raquel E. Gur, Stephan Heckers, Franz Hefti, David M. Holtzman, Steven E. Hyman, Nancy Ip, Cynthia Joyce, Tobias Kaiser, Edward H. Koo, Walter J. Koroshetz, Katja S. Kroker, Robert C. Malenka, Isabelle Mansuy, Eliezer, Masliah, Yuan Mei, Andreas Meyer-Lindenberg, Lennart Mucke, Pierluigi Nicotera, Karoly Nikolich, Michael J. Owen, Menelas N. Pangalos, Alvaro Pascual-Leone, Joel S. Perlmutter, Trevor W. Robbins, Lee L. Rubin, Akira Sawa, Mareike Schnaars, Bernd Sommer, Maria Grazia Spillantini, Laura Spinney, Matthew W. State, Marius Wernig
Table of contents:
1 Introduction
Karoly Nikolich and Steven E. Hyman
Neurodevelopmental Disorders: A New Beginning
2 What Do We Know about Early Onset Neurodevelopmental Disorders?
Thomas Bourgeron
3 Psychotic Disorders and the Neurodevelopmental Continuum Michael J. Owen
4 Neurodevelopmental Disorders: What Is to Be Done?
Stephan Heckers, Steven E. Hyman, Thomas Bourgeron, Bruce N. Cuthbert, Raquel E. Gur, Cynthia Joyce, Andreas Meyer-Lindenberg, Michael J. Owen, and Matthew W. State
Neurodegenerative Diseases: Coming Unstuck
5 Neurodegenerative Diseases: Where Are We Not Looking for Answers?
Walter J. Koroshetz and Lennart Mucke
6 Preclinical and Clinical Understanding: Major Gaps in Our Understanding and Capabilities
Edward H. Koo
7 Neurodegenerative Diseases: What Is to Be Done?
David M. Holtzman, Karoly Nikolich, Menelas N. Pangalos, Karl Broich, Nancy Y. Ip, Edward H. Koo, Walter J. Koroshetz, Eliezer Masliah, Lennart Mucke, Pierluigi Nicotera, Mareike Schnaars, and Maria Grazia Spillantini
New Tools to Drive Future Therapies
8 How Might We Get from Genes to Circuits to Disease?
Tobias Kaiser, Yuan Mei, and Guoping Feng
9 How Do We Define and Modulate Circuits in Animals That Are Relevant to Pathophysiology in Humans?
Joel S. Perlmutter
10 Pathophysiological Toolkit: Genes to Circuits
Gül Dölen, Robert C. Malenka, Joel S. Perlmutter, Nils Brose, Richard Frackowiak, Bruce N. Cuthbert, Ilka Diester, Isabelle Mansuy, Katja S. Kroker, Tobias M. Boeckers, Alvaro Pascual-Leone, Guoping Feng
From Cellular and Animal Models to Patients
11 Using a Stem Cell-Based Approach to Model Neurodegenerative Disease: Where Do We Stand?
Lee L. Rubin
12 From Rodent Behavioral Models to Human Disorders
Trevor W. Robbins
13 Bridging the Gap between Patients and Models
Ilka Diester, Franz Hefti, Isabelle Mansuy, Alvaro Pascual-Leone, Trevor W. Robbins, Lee L. Rubin, Akira Sawa, Marius Wernig, Gül Dölen, Steven E. Hyman, Lennart Mucke, Karoly Nikolich, and Bernd Sommer
Epilogue
14 The Revolution Has Begun
Steven E. Hyman and Karoly Nikolich
People also search for:
translational neuroscience
msc translational neuroscience
sheffield institute for translational neuroscience
mphil in basic and translational neuroscience
journal of neurology and translational neuroscience
Tags: Karoly Nikolich, Steven Hyman, Translational Neuroscience, Toward New Therapies