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The Orexin Hypocretin System Physiology and Pathophysiology 1st Edition by Michihiro Mieda PhD, Takeshi Sakurai MD PhD, Seiji Nishino MD PhD, Takeshi Sakurai MD PhD ISBN 9781592599509 1592599508

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The Orexin Hypocretin System Physiology and Pathophysiology 1st Edition Michihiro Mieda Phd Digital Instant Download

Author(s): Michihiro Mieda PhD, Takeshi Sakurai MD, PhD (auth.), Seiji Nishino MD, PhD, Takeshi Sakurai MD, PhD (eds.)
ISBN(s): 9781592599509, 1592599508
Edition: 1
File Details: PDF, 5.00 MB
Year: 2005
Language: english
SKU: EB-4413748 Category: Tags: , , , , ,

The Orexin Hypocretin System Physiology and Pathophysiology 1st Edition by Michihiro Mieda PhD, Takeshi Sakurai MD  PhD, Seiji Nishino MD  PhD, Takeshi Sakurai MD  PhD- Ebook PDF Instant Download/Delivery: 9781592599509, 1592599508
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Product details: 

ISBN 10: 1592599508

ISBN 13: 9781592599509

Author: Michihiro Mieda PhD, Takeshi Sakurai MD, PhD, Seiji Nishino MD, PhD, Takeshi Sakurai MD  PhD

The document discusses the Orexin/Hypocretin System, detailing its physiology and pathophysiology, particularly in relation to narcolepsy. It highlights the significance of orexin/hypocretin deficiency in narcolepsy diagnosis and treatment, emphasizing ongoing research into therapeutic options. The book compiles various studies and insights from multiple contributors, reflecting the complexity of the system’s role in sleep regulation and other physiological functions.
 

Table of contents: 

PART I. HISTORY

1 History and Overview of Orexin/Hypocretin Research: From Orphan GPCR to Integrative Physiology Michihiro Mieda and Takeshi Sakurai

PART II. OVERVIEW OF THE OREXIN/HYPOCRETIN NEURONAL SYSTEM

2 Orexin and Orexin Receptors Takeshi Sakurai

3 Orexin Projections and Localization of Orexin Receptors Jacob N. Marcus and Joel K. Elmquist

4 Neuronal Responses to Hypocretin/Orexin. Anthony N. van den Pol and Claudio Acuna-Goycolea

5 Afferent System of Orexin Neurons Akihiro Yamanaka

PART III. ASSESSMENT OF OREXIN/HYPOCRETIN FUNCTIONS IN TISSUE AND BIOLOGICAL FLUIDS

6 Hypocretin Measurements in the CSF, and Blood and Brain Tissue: Basic and Clinical Applications Seiji Nishino

7 Hypocretin Receptor-Activated G Proteins Revealed by [35S]GTPYS Autoradiography René Bernard, Ralph Lydic, and Helen A. Baghdoyan

PART IV. PHYSIOLOGY

A. Orexin/Hypocretin System and Hypothalamic Function

8 Orexin System and Feeding Behavior. Takeshi Sakurai

9 Orexins and the Autonomic Nervous System Tetsuro Shirasaka and Masamitsu Nakazato

10 Neuroendocrine Role of the Orexins (Hypocretins) Shahrad Taheri

11 The Orexin/Hypocretin System and Stress and Emotion. Yoichi Ueta and Hiroaki Fujihara

B. Orexins/Hypocretins and Sleep Regulation

12 Hypocretin as a Wakefulness Regulatory Peptide Luis de Lecea and J. Gregor Sutcliffe

13 Hypocretin/Orexin Tonus and Vigilance Control Yasushi Yoshida and Seiji Nishino

14 Hypocretin System and Aminergic and Cholinergic Systems in the Control of Vigilance Krister S. Eriksson and Helmut L. Haas

15 Orexin and Hypothalamic Control of Sleep and Waking Rodrigo A. España and Thomas E. Scammell

16 Hypocretin/Orexin and Motor Function. Jerome M. Siegel

PART V. PATHOPHYSIOLOGY: NARCOLEPSY AND OREXIN/HYPOCRETIN DEFICIENCY

A. Orexin/Hypocretin Deficiency and Narcolepsy

17 Overview of Human Narcolepsy. Scott Fromherz and Emmanuel Mignot

18 Canine Models of Narcolepsy Seiji Nishino

19 Rodent Models of Human Narcolepsy-Cataplexy. Michihiro Mieda and Masashi Yanagisawa

B. Orexin/Hypocretin Deficiency in Human Narcolepsy and Other Conditions

20 Hypocretin Deficiency in Human Narcolepsy: Mutation Screening, Neuropathology, and CSF Hypocretin-1 Level Patrice Bourgin, Jamie M. Zeitzer, and Emmanuel Mignot

21 Hypocretin Status in Neurological Disorders in Relation to Excessive Sleepiness and Cataplexy

Takashi Kanbayashi, Junko Arii, Hideaki Kondo, Tetsuo Shimizu, and Seiji Nishino

22 Hypocretin Measures in Psychiatric Disorders. Ronald M. Salomon

23 Neuroendocrinology of Human Narcolepsy Gert Jan Lammers, Sebastiaan Overeem, and Hanno Pijl

24 Narcolepsy and Autoimmunity Shahrad Taheri, Jose Paterno, Ling Lin, and Emmauel Mignot

C. Treatment/Pharmacology

25 Pharmacology of Orexin/Hypocretin Peptides and Small Molecules Stephen J. Perry, David A. Schwarz, and Richard A. Maki

26 Rescue of Narcoleptic Orexin Neuron-Ablated Mice by Ectopic Overexpression of Orexin Peptides Michihiro Mieda, Jon T. Willie, and Takeshi Sakurai

27 Hypocretin/Orexin Replacement Therapy in Hypocretin/Orexin-Deficient Narcolepsy: An Overview

Nobuhiro Fujiki and Seiji Nishino

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Tags: Michihiro Mieda PhD, Takeshi Sakurai MD PhD, Seiji Nishino MD PhD, Takeshi Sakurai MD PhD, The Orexin Hypocretin, System Physiology