Name: Assessing Bioavailablility of Drug Delivery Systems Mathematical Modeling 1st Edition by Jean Maurice Vergnaud, Iosif Daniel Rosca ISBN 0849330440 978-0849330445
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ISBN 10: 0849330440

ISBN 13: 978-0849330445

Author: Jean-Maurice Vergnaud, Iosif-Daniel Rosca

Exploring how to apply in vitro/in vivo correlations for controlled release dosage forms, Bioavailability of Drug Delivery Systems: Mathematical Modeling clearly elucidates this complex phenomena and provides a guide for the respective mathematical modeling. The book introduces mathematical modeling methods for calculating the profiles of plasma levels obtained with controlled release dosage forms and provides examples and case studies to illustrate the techniques employed. The author has considerable experience in investigating mathematical fundamentals that are related to pharmaco- and toxicokinetics, modified-release drug products, physiologic pharmacokinetics and statistical treatment in clinical situations. The mathematical models he has developed are particularly powerful because they account for such major parameters as the kinetics of drug release controlled by diffusion or by erosion, and the kinetics of absorption into and elimination out of the plasma. They are also able to solve the problem of determining the drug level in plasma as a result of patient non-compliance, incorrect dosage, and incorrect frequency and to determine the best dosage forms necessary for therapy. Using master curves, the book highlights the inter-variability of the patients often expressed by different responses towards a drug. Thus, after evaluating a patient’s pharmacokinetic parameters, the dose can be adapted to the patient, with the expectation of decreasing the side effects for each patient. Using dimensionless numbers in repeated doses, either for the time or for the plasma drug concentration, makes the master curves useful for every drug, providing that its pharmacokinetics was linear. These master curves address clear information either to the patients or to the therapists in a didactic and easy way. The patients can see from first look the effects of non-compliance and therapists can see the dramatic effects of inter-variability of patients towards a drug. Drug discovery and dosage forms have become an increasingly time-consuming and expensive process. The development of a single drug can leave behind more than 10 to 15 years of work. Discussing time and cost-effective methods as alternatives to conventional in vivo methods, the book helps you analyze and integrate in vitro/in vivo correlations and apply them to patient care and drug consultation situations.

1. Definitions
1.1 Drugs (Active Agents) and Their Supply Forms (Dosage Forms)
1.2 Biopharmaceutics and Its Goal
1.3 Pharmacokinetics
1.4 Pharmacodynamics
1.5 Liberation of the Drug
1.6 Membranes
1.7 Bioavailability
1.8 Absorption of the Drug in the Blood
1.9 Distribution of the Drug
1.10 Elimination of the Drug
1.11 Therapeutic Index
1.12 Determination of the Pharmaceutical Parameters

2. Intravenous Administration
2.1 Administration of a Single Dose
2.2 Repeated Intravenous Injections (DIV)
2.3 Continuous Intravenous Infusion (CIV)
2.4 Repeated Dosage at Constant Flow Rate

3. Oral Dosage Forms with Immediate Release
3.1 Single Dose
3.2 Effect of the Pharmacokinetic Parameters’ Values
3.3 Multiple Oral Doses
3.4 Area under the Curve with Oral Dosage Forms
3.5 Comparison Between Oral and I.V. Drug Delivery

4. Kinetics of Drug Release from Oral Sustained Dosage Forms
4.1 Drug Release Controlled by Diffusion
4.2 Drug Release Controlled by Erosion
4.3 Comparisons and Other Kinetics of Release

5. Bibliography on In Vitro-In Vivo Correlations
5.1 General Survey on In Vitro-In Vivo Problems
5.2 In Vitro-In Vivo Correlations for Oral Immediate-Release Dosage Forms
5.3 In Vitro-In Vivo Correlations with Oral Sustained-Release Dosage Forms

6. Plasma Drug Level with Oral Diffusion-Controlled Dosage Forms
6.1 Methods of Calculation
6.2 Results Obtained for a Single Dose
6.3 Sustained Release with Repeated Doses
6.4 Prediction of the Characteristics of the Dosage Form

7. Plasma Drug Level with Erosion-Controlled Dosage Forms
7.1 Method of Calculation
7.2 Plasma Drug Profile with a Single Dose
7.3 Plasma Drug Profile with Repeated Multidoses
7.4 Prediction of the Characteristics of the Dosage Forms

8. Effect of Patient’s Noncompliance
8.1 Limited Reliability of the Patient
8.2 Noncompliance with Erosion-Controlled Dosage Forms
8.3 Noncompliance with Diffusion-Controlled Dosage Forms

9. Drug Transfer in Various Tissues
9.1 Drug Transfer into and through the Lung and Bronchial Mucus
9.2 Drug Transfer into the Blister Fluid
9.3 Drug Transfer into Endocarditis

10. Transdermal Therapeutic Systems
10.1 General Mechanisms of Drug Delivery
10.2 Overview of the Skin and Its Role
10.3 Calculation of the Drug Transport
10.4 Results for the Transdermal Delivery of Metropolol
10.5 Effect of the Characteristics of the TTS
10.6 Effect of the Parameters of the Skin

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Tags: Jean Maurice Vergnaud, Iosif Daniel Rosca, Assessing Bioavailablility, Systems Mathematical

Assessing Bioavailablility of Drug Delivery Systems Mathematical Modeling 1st Edition by Jean Maurice Vergnaud, Iosif Daniel Rosca ISBN 0849330440 978-0849330445

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