Acetylsalicylic Acid 3rd Edition by Karsten Schror ISBN 3110746417 9783110746419

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ISBN 10: 3110746417 
ISBN 13: 9783110746419
Author: Karsten Schror 

Written by a leading expert on Aspirin-related research, this is the most comprehensive treaty of the history, pharmacological effects and clinical applications of one of the most successful drugs ever.

The text is written with a wide audience in mind and to be readily understandable for clinicians, pharmacists, biomedical researchers and pharmacologists alike.

This third completely revised edition contains the latest results of clinical and pharmacological research on Acetylsalicylic acid, addressing the multiple pharmacological properties of this famous drug with a balanced view on their translation into clinical practice, including prevention and treatment of cardiovascular diseases, thromboinflammation and colorectal cancer.

Acetylsalicylic Acid 3rd Table of contents:

Part I: Historical Perspectives and Basic Chemistry

• Chapter 1: The Discovery and Early History of Salicylates

  • From Willow Bark to Salicylic Acid

  • Felix Hoffmann and the Synthesis of Acetylsalicylic Acid

  • Early Therapeutic Uses and Aspirin’s Rise to Prominence

• Chapter 2: Chemical Properties and Formulation of Acetylsalicylic Acid

  • Chemical Structure and Synthesis

  • Stability, Degradation, and Impurities

  • Different Formulations (Tablets, Enteric-Coated, Buffering, Sustained Release)

  • Pharmacopeial Standards

Part II: Pharmacodynamics and Pharmacokinetics

• Chapter 3: Absorption, Distribution, Metabolism, and Excretion of Aspirin

  • Routes of Administration and Bioavailability

  • Hydrolysis to Salicylic Acid

  • Distribution to Tissues

  • Metabolic Pathways and Excretion (Renal and Biliary)

  • Pharmacokinetics in Special Populations (e.g., elderly, renal/hepatic impairment)

• Chapter 4: Mechanism of Action: Inhibition of Cyclooxygenases (COX-1 and COX-2)

  • Prostaglandin Synthesis Pathway

  • Irreversible Acetylation of COX-1

  • Differential Effects on COX-1 and COX-2

  • Impact on Thromboxane A2 and Prostaglandins

  • Alternative Mechanisms (e.g., independent of COX, nitric oxide modulation)

Part III: Clinical Applications

• Chapter 5: Analgesic and Antipyretic Effects

  • Mechanism of Pain and Fever Reduction

  • Clinical Efficacy in Various Pain Syndromes

  • Comparison with Other NSAIDs

• Chapter 6: Anti-inflammatory Properties

  • Mechanism of Inflammation Resolution

  • Use in Rheumatic Diseases (e.g., Rheumatoid Arthritis, Osteoarthritis – historical context and current use)

  • Role in Gout and Other Inflammatory Conditions

• Chapter 7: Antiplatelet Effects: Primary and Secondary Prevention of Cardiovascular Disease

  • Aspirin’s Role in Platelet Aggregation Inhibition

  • Primary Prevention of Myocardial Infarction and Stroke

  • Secondary Prevention of Cardiovascular Events

  • Dosage Considerations for Antiplatelet Therapy

  • Aspirin Resistance and Genetic Factors

• Chapter 8: Aspirin in Cerebrovascular Disease

  • Prevention of Ischemic Stroke and Transient Ischemic Attack (TIA)

  • Use in Acute Ischemic Stroke

• Chapter 9: Emerging Roles: Aspirin and Cancer Prevention

  • Epidemiological Evidence for Cancer Chemoprevention (especially colorectal cancer)

  • Proposed Mechanisms (COX-dependent and COX-independent)

  • Risk-Benefit Considerations for Cancer Prevention

• Chapter 10: Aspirin in Other Therapeutic Areas

  • Preeclampsia Prevention

  • Potential Role in Diabetes, Alzheimer’s Disease, etc.

  • Use in Kawasaki Disease

Part IV: Adverse Effects, Contraindications, and Interactions

• Chapter 11: Gastrointestinal Side Effects

  • Mechanism of Gastric Mucosal Injury

  • Gastric Ulcers, Bleeding, and Perforation

  • Prevention and Management Strategies

• Chapter 12: Bleeding Complications

  • Risk Factors for Hemorrhage

  • Management of Aspirin-Induced Bleeding

  • Interactions with Anticoagulants and Other Antiplatelet Agents

• Chapter 13: Renal and Hepatic Effects

  • Impact on Kidney Function

  • Liver Toxicity (Rare)

• Chapter 14: Hypersensitivity Reactions

  • Aspirin-Exacerbated Respiratory Disease (AERD)

  • Urticaria and Angioedema

  • Mechanism of Hypersensitivity

• Chapter 15: Reye’s Syndrome

  • Epidemiology and Clinical Features

  • The Link to Aspirin Use in Children

  • Current Guidelines

• Chapter 16: Drug Interactions

  • Interactions with NSAIDs, Warfarin, Heparin, SSRIs, etc.

  • Pharmacodynamic and Pharmacokinetic Interactions

Part V: Future Perspectives and Research

• Chapter 17: Aspirin in Specific Patient Populations

  • Elderly Patients

  • Pediatric Use (where appropriate)

  • Patients with Renal or Hepatic Impairment

  • Pregnancy and Lactation

• Chapter 18: New Insights and Research Directions

  • Aspirin’s Effects on Inflammation Resolution Pathways

  • Genetic Factors Influencing Response and Side Effects

  • Novel Formulations and Delivery Systems

  • The Ongoing Debate on Aspirin’s Role in Various Conditions

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