A Practical Guide to the Histology of the Mouse 1st Edition by Cheryl Scudamore ISBN 978-1119941200 1119941202
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Product details:
ISBN 10: 1119941202
ISBN 13: 978-1119941200
Author: Cheryl L. Scudamore
A Practical Guide to the Histology of the Mouse provides a full-colour atlas of mouse histology. Mouse models of disease are used extensively in biomedical research with many hundreds of new models being generated each year. Complete phenotypic analysis of all of these models can benefit from histologic review of the tissues.
This book is aimed at veterinary and medical pathologists who are unfamiliar with mouse tissues and scientists who wish to evaluate their own mouse models. It provides practical guidance on the collection, sampling and analysis of mouse tissue samples in order to maximize the information that can be gained from these tissues. As well as illustrating the normal microscopic anatomy of the mouse, the book also describes and explains the common anatomic variations, artefacts associated with tissue collection and background lesions to help the scientist to distinguish these changes from experimentally- induced lesions.
This will be an essential bench-side companion for researchers and practitioners looking for an accessible and well-illustrated guide to mouse pathology.
Written by experienced pathologists and specifically tailored to the needs of scientists and histologists
Full colour throughout
Provides advice on sampling tissues, necropsy and recording data
Includes common anatomic variations, background lesions and artefacts which will help non-experts understand whether histologic variations seen are part of the normal background or related to their experimental manipulation
Table of contents:
Chapter 1
Necropsy of the mouse
Lorna Rasmussen and Elizabeth McInnes
1.1 Recording of findings
1.2 Bleeding technique
1.3 Perfusion
1.4 External examination
1.5 Weighing of organs
1.6 Positioning of mouse for necropsy and removing the skin
1.7 Opening the abdominal cavity and exposing organs
1.8 Removing the ribcage to expose lungs and heart
1.9 Removing the brain and spinal cord
1.10 Collecting and fixing tissue samples References
Chapter 2
Practical approaches to reviewing and recording pathology data Cheryl L. Scudamore
2.1 Sample selection and trimming patterns
2.2 Controls
2.3 Standardizing terminology
2.4 Microscopic terminology
2.5 Recording pathology data
2.6 Quantitative versus semiquantitative analysis
2.7 Semiquantitative techniques
2.8 Quantitative techniques References
Chapter 3
Gastrointestinal system Cheryl L. Scudamore
3.1 Background and development
3.2 Oral cavity
3.3 Salivary glands
3.4 Stomach and intestines
3.5 Liver
3.6 Pancreas
Chapter 4
Cardiovascular system
Cheryl L. Scudamore
4.1 Background and development
4.2 Sampling techniques and morphometry
4.3 Artefacts
4.4 Anatomy and histology of the heart
4.5
Anatomy and histology of the blood vessels
References
Chapter 5
Urinary system
Elizabeth McInnes
5.1 Background and development
5.2 Sampling techniques
5.3 Artefacts
5.4 Background lesions
5.5 Anatomy and histology
References
Chapter 6
Reproductive system
Cheryl L. Scudamore
6.1 Background and development of the male and female reproductive tract
6.2 Female reproductive tract
6.3 Male reproductive tract
References
Chapter 7
Endocrine system
Ian Taylor
7.1 Introduction
7.2 Adrenals
7.3 Pituitary
7.4 Thyroids and parathyroids
Chapter 8
Nervous system
Aude Roulois
8.1 Introduction
8.2 Necropsy
8.3 Fixation/perfusion
8.4 Trimming
8.5 Special stains and techniques
8.6 Microscopic examination
8.7 Normal histology-juvenile – CNS and PNS
8.8 Artefacts – CNS and PNS
8.9 Pathological changes and background pathology – CNS and PNS
8.10 Acknowledgment
References
Useful website resources
Chapter 9
Lymphoid and haematopoietic system
Ian Taylor
9.1
Introduction
9.2
Lymph nodes
9.3
Spleen
9.4
MALT (mucosa-associated lymphoid tissue)
9.5
Thymus
9.6 Bone marrow References
Chapter 10
Integument and adipose tissue
Cheryl L. Scudamore
10.1 Background and development
10.2 Sampling technique
10.3 Anatomy and histology
References
Chapter 11
The respiratory system
Elizabeth McInnes
11.1 Background and development
11.2 Embryology
11.3 Anatomy and histology of the respiratory system
11.4 Upper respiratory tract
11.5 Lower respiratory tract
References
Chapter 12
Special senses
Cheryl L. Scudamore
12.1 Background and development
12.2 Sampling technique for the eye
12.3 Artefacts
12.4 Anatomy and histology of the eye and associated glands
12.5 Background and development of the ear
12.6 Sampling technique for the ear and associated structures
12.7 Anatomy and histology of the ear and associated glands References
Chapter 13
Musculoskeletal system
Cheryl L. Scudamore
13.1 Background and development
13.2 Sampling techniques
13.3 Anatomy and histology References
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