What s Wrong With My Mouse Behavioral Phenotyping of Transgenic and Knockout Mice Second Edition by Jacqueline Crawley ISBN 0471471925 978-0471471929
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Product details:
ISBN 10: 0471471925
ISBN 13: 978-0471471929
Author: Jacqueline N. Crawley
Dr. Jacqueline N. Crawley, author of the First and Second Editions of What’s Wrong with My Mouse? Behavioral Phenotyping of Transgenic and Knockout Mice,continues to field calls and e-mails from molecular geneticists who ask: how do I run behavioral assays to find out what’s wrong with my mouse?
Turn to What’s Wrong with My Mouse? to discover the wealth of mouse behavioral tasks and to get the guidance you need to select the best methods and necessary controls. Chapters are organized by behavioral domain, including measurements of general health, motor functions, sensory abilities, learning and memory, feeding and drinking, reproductive, social, emotional, and reward behaviors in mutant mice. Throughout the chapters, new behavioral tasks and new research discoveries have been added, bringing the Second Edition up to date with the latest science. In addition, the Second Edition includes two new chapters:
“Neurodevelopment and Neurodegeneration” discusses mouse behavioral tasks relevant to neurodevelopmental diseases, such as mental retardation and autism, and to neurodegenerative diseases, such as Alzheimers, Parkinsons, Huntingtons, and amyotrophic lateral sclerosis.
“Putting It All Together” recommends strategies for optimizing a battery of behavioral phenotyping tests to address your specific hypotheses about gene functions.
The final chapter, “The Next Generation,” examines new and emerging technologies.
Throughout the book, the use of behavioral testing equipment is illustrated with photographs, diagrams, and representative data. Examples of behavioral tasks successfully applied to transgenic and knockout mouse models are provided, as well as references to the primary literature and step-by-step methods protocols. These features, along with a comprehensive index, listings of database and vendor websites, and an extensive list of references, make this book a valuable and practical resource for students and researchers.
Table of contents:
Chapter 1 Designer Mice
Scope and sourcebooks
Chapter 2 Of Unicorns and Chimeras
How to generate a line of transgenic or knockout mouse for behavioral phenotyping
Chapter 3 General Health
Give your mouse a physical
Chapter 4 Motor Functions
Open field, holeboard, rotarod, balance, grip, circadian activity, circling, stereotypy, ataxic gait, seizures
Chapter 5 Sensory Abilities
Olfaction, vision, hearing, taste, touch, nociception
Chapter 6 Learning and Memory
Morris swim task, spatial mazes, cued and contextual conditioning, conditioned taste aversion, conditioned eyeblink, olfactory discrimination, social recognition, passive avoidance, schedule controlled operant tasks, motor learning, attention
Chapter 7 Feeding and Drinking
Daily consumption, restricted access, choice tests, microstructural analysis
Chapter 8 Reproductive Behaviors
Sexual and parental behaviors
Chapter 9 Social Behaviors
Social interaction, nesting, grooming, juvenile play, aggression
Chapter 10 Emotional Behaviors: Animal Models of Psychiatric Diseases
Mouse models of fear, anxiety, depression, schizophrenia
Chapter 11 Reward
Self-administration of addictive drugs, conditioned place preference
Chapter 12 Neurodevelopment and Neurodegeneration
Assaying behaviors in infant, juvenile, and aged mice
Chapter 13 Putting It All Together
Choice of tests, order of testing, number of mice, equipment, housing and testing environment
Chapter 14 The Next Generation
Conditional and inducible mutations, viral vector gene delivery, RNA silencing, quantitative trait loci analysis, DNA microarrays, chemical mutagenesis, gene therapy, ethical issues
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Tags: Jacqueline Crawley, What s Wrong, My Mouse, Behavioral Phenotyping