Drug Delivery Systems in Cancer Therapy Cancer Drug Discovery and Development 2024th Edition by Dennis Brown ISBN 978-0896038882 0896038882

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Product details: 

ISBN 10:  0896038882

ISBN 13: 978-0896038882

Author: Dennis M. Brown

Leading experts survey the currently available technologies designed to improve the delivery of today’s cancer chemotherapeutic agents. The authors review both the theoretical and practical considerations governing conventional and nonconventional methods of drug administration, and identify promising opportunities for product development. In their outline and discussion of the use of novel formulation technologies-including synthetic polymers and biomaterials for prolonged or sustained drug release to achieve potentially greater therapeutic effect-they profile those technologies that have resulted in a number of approved and late-stage clinical products.

Table of contents: 

PART I: Pharmacological Considerations for Drug Delivery Systems in Cancer Medicine
Systemically Administered Drugs
Reginald B. Ewesuedo and Mark J. Ratain

Regional Administration of Antineoplastic Drugs
Maurie Markman

Theoretical Analyses and Simulations of Anticancer Drug Delivery
Ardith W. El-Kareh and Timothy W. Secomb

PART II: Technologies Available for Use in Cancer Drug Delivery Systems
Biopolymers for Parenteral Drug Delivery in Cancer Treatment
Wolfgang Friess

Hydrogels in Cancer Drug Delivery Systems
Sung-Joo Hwang, Namjin Baek, Haesun Park, and Kinam Park

Microparticle Drug Delivery Systems
Duane T. Birnbaum and Lisa Brannon-Peppas

Polyethylene Glycol Conjugation of Protein and Small Molecule Drugs: Past, Present, and Future
Robert G. L. Shorr, Michael Bentley, Simon Zhao, Richard Parker, and Brendan Whittle

Emulsions as Anticancer Delivery Systems
S. Esmail Tabibi

PART III: Current Applications – Products Approved or in Advanced Clinical Development
Liposomal Drug Delivery Systems for Cancer Therapy
Daryl C. Drummond, Dmitri Kirpotin, Christopher C. Benz, John W. Park, and Keelung Hong

10 Gliadel: A New Method for the Treatment of Malignant Brain Tumors

Francesco DiMeco, Henry Brem, Jon D. Weingart, and Alessandro Olivi

11 Intralesional Chemotherapy with Injectable Collagen Gel

Formulations

Elaine K. Orenberg

12 Sustained-Release Drug Delivery with DepoFoam

Sankaram B. Mantripragada and Stephen B. Howell

Cancer Vaccines

Susanne Osanto

PART IV: FUTURE DIRECTIONS:

NOVEL CANCER DRUG TARGETS AND DELIVERY SYSTEMS

Gene Therapy of Cancer

Susanne Osanto

15 Progress in Antisense Technology

Stanley T. Crooke

16 Tumor Vaccines

Francesco M. Marincola

17 Diagnosis and Treatment of Human Disease

Using Telomerase As a Novel Target

Lynne W. Elmore and Shawn E. Holt

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Tags: Dennis Brown, Drug Delivery, Cancer Therapy, Drug Discovery